JRF Global is in the process of expanding its chemistry services with addition of a custom synthesis group. The company infrastructure, consisting of dedicated synthesis lab with two walk-in hoods and six fume hoods with international safety standards, will be operational by September 2016.

JRF instrumentation for custom synthesis will include analytical chemistry facility consisting of NMR (1D & 2D), LC-MS, HPLC, prep-HPLC, Flash column chromatography, Microwave and Lyophilisers to support the company’s synthetic chemistry group.

JRF team consists of synthetic chemists and analytical chemists with profound international experience, problem solving skills, and many years of practical industrial experience of working in top-notch CROs in India. Our company chemists have broad range of experience in custom synthesis. They have worked with many global pharma and agrochemical companies.

JRF synthesis chemistry expertise consists of carbocyclic chemistry, heterocyclic chemistry, peptide chemistry, carbohydrate chemistry, transition metal catalysed coupling reactions, chiral chemistry, stereo-selective synthesis, fluorine chemistry and nucleotide/ nucleoside chemistry. The company offers synthesis of building blocks, scaffolds, focused libraries, reference standards and impurities etc.

JRF offers

• Very high success rates
• Speed and flexibility
• Mile stone and/or FTE-based approaches from mg to multi gram scale
• Attractive cost schemes affordable for integrated services

Capabilities

• Synthesis of impurity (impurity profiling, i.e., isolation, characterisation & synthesis of impurities)
• Synthesis of metabolites (for pharmaceutical and agrochemical products )
• Synthesis of reference compounds, intermediates, novel scaffolds, NCEs, analogues for Lead Generation/Lead Optimisation and focused libraries of up to 50 compounds for a scaffold
• Scale: mg to 100 g

Additional support

• SCM: Online chemical procurement process, in-house inventory, vendor list
• IP & Confidentiality (CDA with employee, code for spectral data, IT security)
• eLNB is offered, as per the customer’s requirement
• Constant monitoring of Turn Around Time (TAT): for SCM, analytical & completion of projects
• Weekly/Biweekly reports and teleconference with clients; periodic review meetings with clients for feedback for areas of improvement

Business models:

• FTE
• FFS
• Integrated: with other services at JRF like impurity isolation, purification and characterisation (impurity profiling), in vitro assays for early discovery, PK studies, toxicology services and safety pharmacology services.

A reputation for excellence
The company prepares custom synthesis compounds of the highest purity and quality. Its custom synthesis experts are ready to offer support for its client’s specific requests, orders, and inquiries. The company guarantees complete confidentiality for its clients.                                       

(Dr. Sridhar Iyer is Deputy Director – Business Development (sridhar.iyer@jrfonline.com) and Dr. Abdul Khadeer
is Principal Scientist – Synthesis (abdul.khadeer@jrfonline.com)
of JRF Global)